- Title
- Development of bilayer tablets with modified release of selected incompatible drugs
- Creator
- Dhiman, Neha; Awasthi, Rajendra; Jindal, Shammy; Khatri, Smriti; Dua, Kamal
- Relation
- Polymers in Medicine Vol. 46, Issue 1, p. 5-15
- Relation
- http://www.polimery.umed.wroc.pl/en/article/2016/46/1/5/
- Publisher
- Wroclaw Medical University
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: The oral route is considered to be the most convenient and commonly-employed route for drug delivery. When two incompatible drugs need to be administered at the same time and in a single formulation, bilayer tablets are the most appropriate dosage form to administer such incompatible drugs in a single dose. Objectives: The aim of the present investigation was to develop bilayered tablets of two incompatible drugs; telmisartan and simvastatin. Materials and Methods: The bilayer tablets were prepared containing telmisartan in a conventional release layer using croscarmellose sodium as a super disintegrant and simvastatin in a slow-release layer using HPMC K15M, Carbopol 934P and PVP K 30 as matrix forming polymers. The tablets were evaluated for various physical properties, drug-excipient interactions using FTIR spectroscopy and in vitro drug release using 0.1M HCl (pH 1.2) for the first hour and phosphate buffer (pH 6.8) for the remaining period of time. The release kinetics of simvastatin from the slow release layer were evaluated using the zero order, first order, Higuchi equation and Peppas equation. Results: All the physical parameters (such as hardness, thickness, disintegration, friability and layer separation tests) were found to be satisfactory. The FTIR studies indicated the absence of interactions between the components within the individual layers, suggesting drug-excipient compatibility in all the formulations. No drug release from the slow-release layer was observed during the first hour of the dissolution study in 0.1M HCl. The release-controlling polymers had a significant effect on the release of simvastatin from the slow-release layer. Thus, the formulated bilayer tablets avoided incompatibility issues and proved the conventional release of telmisartan (85% in 45 min) and slow release of simvastatin (80% in 8 h). Conclusions: Stable and compatible bilayer tablets containing telmisartan and simvastatin were developed with better patient compliance as an alternative to existing conventional dosage forms.
- Subject
- sustained release; release kinetics; bilayer tablet; incompatible; conventional release
- Identifier
- http://hdl.handle.net/1959.13/1344024
- Identifier
- uon:29308
- Identifier
- ISSN:0370-0747
- Rights
- This article is licensed under a Creative Commons (CC BY-NC-ND 4.0)
- Language
- eng
- Full Text
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